We proudly present the new article by Philipp Kastl, Sandro Altamura, Martina Muckenthaler, and Ursula Klingmüller from our FerrOs Research Group on "Erythropoietin-driven dynamic proteome adaptations during erythropoiesis prevent iron overload in the developing embryo" that was just published in Cell Reports (https://www.cell.com/action/showPdf?pii=S2211-1247%2822%2901192-5).
At our 2nd FerrOs Retreat Alessa Wagner was awarded with our „Back To Science” Grant to join the lab of Prof. Maja Vujic-Spasic in Ulm after her maternal leave.
On June 29th – July 1st we met in Riederau at the Ammersee at our 2nd FerrOs Retreat. Since we were not able to meet face-to-face at our 1st retreat, we were all more than happy to get together in real life and listen to the presentations of our eight FerrOs projects.
Since the University of Pennsylvania announced their breakthrough discovery of the FOP gene ACVR1 at April 23, 2006, this date is now celebrated as International FOP Awareness Day! This year marks the 16th anniversary of the discovery of the FOP gene meaning 16 years of hope, progress and determination to find a cure.
The Leslie Dan Faculty of Pharmacy from University of Toronto, Canada, awarded six Alumni Awards (https://www.pharmacy.utoronto.ca/news-announcements/exceptional-alumni-recognized-through-second-annual-alumni-awards) in different categories recognizing the remarkable achievements of alumni in pharmacy practice and pharmaceutical sciences.
We proudly present the new article by Silvia Colucci, Sandro Altamura and Martina Muckenthaler from our FerrOs Research Group on "Liver Sinusoidal Endothelial Cells Suppress Bone Morphogenetic Protein 2 Production in Response to TGFβ Pathway Activation" that was just published in Hepatology (https://pubmed.ncbi.nlm.nih.gov/33982327/).
Our second FerrOs Webinar took place on September 28th. The FerrOs members were very keen on listening to the excellent talk of Delphine Meynard, who presented her newest work on the role of matripase-2 as a novel therapeutic target in diseases with ineffective hematopoiesis. Besides the stimulating talk, it was great to see each other again and get to know new members of the FerrOs consortium.
We proudly present our new review on "Shaping the bone through iron and iron-related proteins" that was just published in Seminars in Hematology (https://doi.org/10.1053/j.seminhematol.2021.06.002).
Meetings during pandemic times – on June 4th we met online at our 1st FerrOs Retreat. Although we were not able to meet face-to-face, we were all very happy to “see” each other online and listen to the eight FerrOs projects so all new members could see what is planned and to discuss how we can interact during the next four years.
Our newly funded Research Unit “FerrOs” officially started in March 2021 and will study the effects of iron metabolism on bone and liver health. Iron deficiency and iron overload are both associated with bone loss and an increased risk of fracture, which markedly limit mobility and autonomy of affected individuals. Thus, iron levels must be balanced to maintain health in general, and in particular bone strength. Therefore, the main aim of our DFG-funded FerrOs consortium (FOR5146) is to decipher the underlying mechanisms of iron regulation and its interactions with bone.
