Publications
Passin V, Ledesma-Colunga MG, Altamura S, Baschant U, Hofbauer LC, Rauner M. Depletion of macrophages and osteoclast precursors mitigates iron overload-mediated bone loss. IUBMB Life. 2025 Jan;77(1):e2928.
Marques O, Horvat NK, Zechner L, Colucci S, Sparla R, Zimmermann S, Neufeldt CJ, Altamura S, Qiu R, Muedder K, Weiss G, Hentze MW, Muckenthaler MU. Inflammation-driven NFκB signaling represses Ferroportin transcription in macrophages via HDAC 1 and 3. Blood. 2024 Accepted
Dogan DY, Hornung I, Pettinato M, Pagani A, Baschant U, Seebohm G, Hofbauer LC, Silvestri L, Rauner M* and Steinbicker AU*. Bone phenotyping of murine hemochromatosis models with deficiencies of Hjv, Alk2 or Alk3 – the influence of sex and the bone compartment. FASEB J. 2024 Nov 30;38(22):e70179. *shared last authorship
Burden AM, Martinez-De la Torre A, Burkard T, Immoos M, Hofbauer LC, Steinbicker AU, Rauner M. Increased risk of fracture among patients with iron overload: a population-based matched cohort study. J Clin Endocrinol Metab. 2024 Nov 18:dgae807.
Comità S, Falco P, Mezzanotte M, Vujić Spasić M, Roetto A. Lack of Hfe and TfR2 in Macrophages Impairs Iron Metabolism in the Spleen and the Bone Marrow. Int J Mol Sci. 2024 Aug 23;25(17):9142.
Ludwig N, Cucinelli S, Hametner S, Muckenthaler MU, Schirmer L. Iron scavenging and myeloid cell polarization. Trends Immunol. 2024 Aug;45(8):625-638.
Baschant U, Fuqua BK, Ledesma-Colunga M, Vulpe CD, McLachlan S, Hofbauer LC, Lusis AJ, Rauner M. Effects of dietary iron deficiency or overload on bone: Dietary details matter. Bone. 2024 Jul;184:117092.
Ludwig N, Cucinelli S, Hametner S, Muckenthaler MU, Schirmer L. Iron scavenging and myeloid cell polarization. Trends Immunol. 2024 Jul 24:S1471-4906(24)00155-8.
Dogan DY, Urzica EI, Hornung I, Kastl P, Oguama D, Fette FM, Nguyen LH, Rosenbauer F, Zacharowski K, Klingmüller U, Gradhand E, von Knethen A, Popp R, Fleming I, Schrader L, Steinbicker AU. Hemojuvelin-mediated hepcidin induction requires both bone morphogenetic protein type I receptors ALK2 and ALK3. Blood Adv. 2024 Jun 11;8(11):2870-2879.
Horvat NK, Chocarro S, Marques O, Bauer TA, Qiu R, Diaz-Jimenez A, Helm B, Chen Y, Sawall S, Sparla R, Su L, Klingmüller U, Barz M, Hentze MW, Sotillo R, Muckenthaler MU. Superparamagnetic Iron Oxide Nanoparticles Reprogram the Tumor Microenvironment and Reduce Lung Cancer Regrowth after Crizotinib Treatment. ACS Nano. 2024 Apr 30;18(17):11025-11041.
Pettinato M, Aghajan M, Guo S, Bavuso Volpe L, Carleo R, Nai A, Pagani A, Altamura S, Silvestri L. A functional interplay between the two BMP-SMAD pathway inhibitors TMPRSS6 and FKBP12 regulates hepcidin expression in vivo. Am J Physiol Gastrointest Liver Physiol. 2024 Mar 1;326(3):G310-G317.
Klement L, Jansakun C, Yan B, Staffer S, Tuma-Kellner S, Altamura S, Muckenthaler M, Merle U, Chamulitrat W. Myeloid-specific deletion of group VIA calcium-independent phospholipase A2 induces pro-inflammatory LPS response predominantly in male mice via MIP-1α activation. Biochim Biophys Acta Mol Basis Dis. 2024 Mar;1870(3):167016.
Ledesma-Colunga MG, Passin V, Vujic Spasic M, Hofbauer LC, Baschant U, Rauner M. Comparison of the effects of high dietary iron levels on bone microarchitecture responses in the mouse strains 129/Sv and C57BL/6J. Sci Rep. 2024 Feb 28;14(1):4887.
Lösser L, Ledesma-Colunga MG, Andrés Sastre E, Scholtysek C, Hofbauer LC, Noack B, Baschant U, Rauner M. Transferrin receptor 2 mitigates periodontitis-driven alveolar bone loss. J Cell Physiol. 2024 Feb;239(2):e31172.
Galy B, Conrad M, Muckenthaler M. Mechanisms controlling cellular and systemic iron homeostasis. Nat Rev Mol Cell Biol. 2024 Feb;25(2):133-155.
Ledesma-Colunga MG, Passin V, Lademann F, Hofbauer LC, Rauner M. Novel Insights into Osteoclast Energy Metabolism. Curr Osteoporos Rep. 2023 Dec;21(6):660-669.
Colucci S, Carvalho Oliveira T, Muckenthaler MU, Marques O. Iron homeostasis in mice: does liver lobe matter? Am J Physiol Gastrointest Liver Physiol. 2023 Nov 1;325(5):G453-G457.
Pettinato M, Dulja A, Colucci S, Furiosi V, Fette F, Steinbicker AU, Muckenthaler MU, Nai A, Pagani A, Silvestri L. FKBP12 inhibits hepcidin expression by modulating BMP receptors interaction and ligand responsiveness in hepatocytes. Am J Hematol. 2023 Aug;98(8):1223-1235.
Samarin J, Fabrowski P, Kurilov R, Nuskova H, Hummel-Eisenbeiss J, Pink H, Li N, Weru V, Alborzinia H, Yildiz U, Grob L, Taubert M, Czech M, Morgen M, Brandstädter C, Becker K, Mao L, Jayavelu AK, Goncalves A, Uhrig U, Seiler J, Lyu Y, Diederichs S, Klingmüller U, Muckenthaler M, Kopp-Schneider A, Teleman A, Miller AK, Gunkel N. Low level of antioxidant capacity biomarkers but not target overexpression predicts vulnerability to ROS-inducing drugs. Redox Biol. 2023 Jun;62:102639.
Ledesma-Colunga MG, Baschant U, Weidner H, Alves TC, Mirtschink P, Hofbauer LC, Rauner M. Transferrin receptor 2 deficiency promotes macrophage polarization and inflammatory arthritis. Redox Biol. 2023 Apr;60:102616.
Olivier RMR, Macke M, Müller JC, Schrader L, Eveslage M, Rauer M, Wempe C, Martens S, Zarbock A, Wagner NM, Karst U, Dogan DY, Steinbicker AU. Perioperative Tracking of Intravenous Iron in Patients Undergoing On-Pump Cardiac Surgery: A Prospective, Single-Center Pilot Trial. Anesth Analg. 2023 Mar 1;136(3):578-587.
Qiu R, Alikhanyan K, Volk N, Marques O, Mertens C, Agarvas AR, Singh S, Pepperkok R, Altamura S, Muckenthaler MU. Repression of the iron exporter ferroportin may contribute to hepatocyte iron overload in individuals with type 2 diabetes. Mol Metab. 2022 Dec;66:101644.
Colucci S, Altamura S, Marques O, Müdder K, Agarvas AR, Hentze MW, Muckenthaler MU. Iron-dependent BMP6 Regulation in Liver Sinusoidal Endothelial Cells Is Instructed by Hepatocyte-derived Secretory Signals. Hemasphere. 2022 Sep 27;6:e773.
Marques O, Weiss G, Muckenthaler MU. The role of iron in chronic inflammatory diseases: from mechanisms to treatment options in anemia of inflammation. Blood. 2022 Nov 10;140:2011-2023.
Chakraborty S, Andrieux G, Kastl P, Adlung L, Altamura S, Boehm ME, Schwarzmüller LE, Abdullah Y, Wagner MC, Helm B, Gröne HJ, Lehmann WD, Boerries M, Busch H, Muckenthaler MU, Schilling M, Klingmüller U. Erythropoietin-driven dynamic proteome adaptations during erythropoiesis prevent iron overload in the developing embryo. Cell Reports 40, 111360 September 20, 2022.
Baschant U, Altamura S, Steele-Perkins P, Muckenthaler MU, Spasić MV, Hofbauer LC, Steinbicker AU, Rauner M. Iron effects versus metabolic alterations in hereditary hemochromatosis driven bone loss. Trends Endocrinol Metab. 2022;33:652-663.
Steinbicker AU. PIGA mutations (can) cause juvenile hemochromatosis. Blood. 2022;139:1273-1275.
Muckenthaler L, Marques O, Colucci S, Kunz J, Fabrowski P, Bast T, Altamura S, Höchsmann B, Schrezenmeier H, Langlotz M, Richter-Pechanska P, Rausch T, Hofmeister-Mielke N, Gunkel N, Hentze MW, Kulozik AE, Muckenthaler MU. Constitutional PIGA mutations cause a novel subtype of hemochromatosis in patients with neurologic dysfunction. Blood. 2022;139:1418-1422.
Girelli D, Busti F, Brissot P, Cabantchik I, Muckenthaler MU, Porto G. Hemochromatosis classification: update and recommendations by the BIOIRON Society. Blood. 2022;139:3018-3029.
Gattermann N, Muckenthaler MU, Kulozik AE, Metzgeroth G, Hastka J. The Evaluation of Iron Deficiency and Iron Overload. Dtsch Arztebl Int. 2021 Dec 10;118:847-856.
Colucci S, Müdder K, Muckenthaler MU, Altamura S. Hfe Is Highly Expressed in Liver Sinusoidal Endothelial Cells But Is Not Needed to Maintain Systemic Iron Homeostasis In Vivo. Hemasphere. 2021 20;6(1):e667.
Huettmann C, Stelljes M, Sivalingam S, Fobker M, Vrachimis A, Exler A, Wenning C, Wempe C, Penke M, Buness A, Ludwig KU, Muckenthaler MU, Steinbicker AU. Iron Deficiency Caused by Intestinal Iron Loss-Novel Candidate Genes for Severe Anemia. Genes (Basel). 2021;12:1869.
Ledesma-Colunga MG, Weidner H, Vujic Spasic M, Hofbauer LC, Baschant U, Rauner M. Shaping the bone through iron and iron-related proteins. Semin Hematol. 2021;58:188-200.
Mertens C, Marques O, Horvat NK, Simonetti M, Muckenthaler MU, Jung M. The Macrophage Iron Signature in Health and Disease. Int J Mol Sci. 2021;22:8457.
Colucci S, Altamura S, Marques O, Dropmann A, Horvat NK, Müdder K, Hammad S, Dooley S, Muckenthaler MU. Liver sinusoidal endothelial cells suppress BMP2 production in response to TGFβ pathway activation. Hepatology. 2021 Oct;74:2186-2200
Colucci S, Marques O, Altamura S. 20 years of Hepcidin: How far we have come. Semin Hematol. 2021;58:132-144.
Altamura S, Müdder K, Schlotterer A, Fleming T, Heidenreich E, Qiu R, Hammes HP, Nawroth P, Muckenthaler MU. Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload. Mol Metab. 2021 Apr 16;51:101235.
Belot A, Gourbeyre O, Palin A, Rubio A, Largounez A, Besson-Fournier C, Latour C, Lorgouilloux M, Gallitz I, Montagner A, Polizzi A, Régnier M, Smati S, Zhang AS, Diaz-Munoz MD, Steinbicker AU, Guillou H, Roth MP, Coppin H, Meynard D. Endoplasmic reticulum stress controls iron metabolism through TMPRSS6 repression and hepcidin mRNA stabilization by RNA-binding protein HuR. Haematologica. 2021 Apr 1;106(4):1202-1206.
Link C, Knopf JD, Marques O, Lemberg MK, Muckenthaler MU. The role of cellular iron deficiency in controlling iron export. Biochim Biophys Acta Gen Subj. 2021 Mar;1865(3):129829.
Pasricha SR, Tye-Din J, Muckenthaler MU, Swinkels DW. Iron deficiency. Lancet. 2021 Jan 16;397(10270):233-248.
Marques O, Neves J, Horvat NK, Altamura S, Muckenthaler MU. Mild Attenuation of the Pulmonary Inflammatory Response in a Mouse Model of Hereditary Hemochromatosis Type 4. Front Physiol. 2021 Jan 13;11:589351.
Tangudu NK, Yilmaz D, Wörle K, Gruber A, Colucci S, Leopold K, Muckenthaler MU, Vujic Spasic M. Macrophage-HFE controls iron metabolism and immune responses in aged mice. Haematologica. 2021 Jan 1;106(1):259-263.
Hannemann A, Nauck M, Völzke H, Weidner H, Platzbecker U, Hofbauer LC, Rauner M*, Baschant U*. Interactions of Anemia, FGF-23, and Bone in Healthy Adults-Results From the Study of Health in Pomerania (SHIP). J Clin Endocrinol Metab. 2021 Jan 1;106(1):e288-e299.
Abtahi S, Driessen JHM, Burden AM, Souverein PC, van den Bergh JP, van Staa TP, Boonen A, de Vries F. Concomitant use of oral glucocorticoids and proton pump inhibitors and risk of osteoporotic fractures among patients with rheumatoid arthritis: a population-based cohort study. Ann Rheum Dis. 2020 Dec 11:annrheumdis-2020-218758.
Traeger L, Schnittker J, Dogan DY, Oguama D, Kuhlmann T, Muckenthaler MU, Krijt J, Urzica EI, Steinbicker AU. HFE and ALK3 act in the same signaling pathway. Free Radic Biol Med. 2020 Nov 20;160:501-505.
Nairz M, Metzendorf C, Vujic-Spasic M, Mitterstiller AM, Schroll A, Haschka D, Hoffmann A, Von Raffay L, Sparla R, Huck CW, Talasz H, Moser PL, Muckenthaler MU, Weiss G. Cell-specific expression of Hfe determines the outcome of Salmonella enterica serovar Typhimurium infection in mice. Haematologica. 2020 Oct 13;Online ahead of print.
Pagani A, Pettinato M, Colucci S, Dulja A, Rauner M, Nai A, Camaschella C, Altamura S, Muckenthaler MU, Silvestri L. Hemochromatosis proteins are dispensable for the acute hepcidin response to BMP2. Haematologica. 2020 Oct 1;105(10):e493.
Ledesma-Colunga MG, Baschant U, Fiedler IAK, Busse B, Hofbauer LC, Muckenthaler MU, Altamura S, Rauner M. Disruption of the hepcidin/ferroportin regulatory circuitry causes low axial bone mass in mice. Bone. 2020 Aug;137:115400.
Wang CY, Xu Y, Traeger L, Dogan DY, Xiao X, Steinbicker AU, Babitt JL. Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3. Blood. 2020 Feb 6;135(6):453-456.
Abtahi S, Driessen JHM, Vestergaard P, van den Bergh J, Boonen A, de Vries F, Burden AM. Secular trends in major osteoporotic fractures among 50+ adults in Denmark between 1995 and 2010. Osteoporos Int. 2019 Nov;30:2217-2223.
Hayes KN, Ban JK, Athanasiadis G, Burden AM, Cadarette SM. Time trends in oral bisphosphonate initiation in Ontario, Canada over 20 years reflect drug policy and healthcare delivery changes. Osteoporos Int. 2019 Nov;30(11):2311-2319
Schreiber JA, Schepmann D, Frehland B, Thum S, Datunashvili M, Budde T, Hollmann M, Strutz-Seebohm N, Wünsch B, Seebohm G. A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors. Commun Biol. 2019 Nov 15;2:420.
Wagner A, Alan B, Yilmaz D, Ahmad M, Liu P, Tangudu NK, Tuckermann JP, Vujic Spasic M. Despite Genetic Iron Overload, Hfe-Hemochromatosis Mice Do Not Show Bone Loss. JBMR Plus. 2019 Jul 26;3(9):e10206.
Mühlfeld C, Neves J, Brandenberger C, Hegermann J, Wrede C, Altamura S, Muckenthaler MU. Air-blood barrier thickening and alterations of alveolar epithelial type 2 cells in mouse lungs with disrupted hepcidin/ferroportin regulatory system. Histochem Cell Biol. 2019 Mar;151(3):217-228.
Rauner M, Baschant U, Roetto A, Pellegrino RM, Rother S, Salbach-Hirsch J, Weidner H, Hintze V, Campbell G, Petzold A, Lemaitre R, Henry I, Bellido T, Theurl I, Altamura S, Colucci S, Muckenthaler MU, Schett G, Komla Ebri D, Bassett JHD, Williams GR, Platzbecker U, Hofbauer LC. Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signaling. Nat Metab. 2019 Jan;1(1):111-124.
Traeger L, Gallitz I, Sekhri R, Bäumer N, Kuhlmann T, Kemming C, Holtkamp M, Müller JC, Karst U, Canonne-Hergaux F, Muckenthaler MU, Bloch DB, Olschewski A, Bartnikas TB, Steinbicker AU. ALK3 undergoes ligand-independent homodimerization and BMP-induced heterodimerization with ALK2. Free Radic Biol Med. 2018 Dec;129:127-137.
Traeger L, Enns CA, Krijt J, Steinbicker AU. The hemochromatosis protein HFE signals predominantly via the BMP type I receptor ALK3 in vivo. Commun Biol. 2018 Jun 8;1:65.
Amiche MA, Abtahi S, Driessen JHM, Vestergaard P, de Vries F, Cadarette SM, Burden AM. Impact of cumulative exposure to high-dose oral glucocorticoids on fracture risk in Denmark: a population-based case-control study. Arch Osteoporos. 2018 Mar 18;13:30.
Lai D, Teng F, Hammad S, Werle J, Maas T, Teufel A, Muckenthaler MU, Dooley S, Vujić Spasić M. Hepatic Smad7 overexpression causes severe iron overload in mice. Blood. 2018 Feb 1;131(5):581-585.
Lucarelli P, Schilling M, Kreutz C, Vlasov A, Boehm ME, Iwamoto N, Steiert B, Lattermann S, Wäsch M, Stepath M, Matter MS, Heikenwälder M, Hoffmann K, Deharde D, Damm G, Seehofer D, Muciek M, Gretz N, Lehmann WD, Timmer J, Klingmüller U. Resolving the Combinatorial Complexity of Smad Protein Complex Formation and Its Link to Gene Expression. Cell Syst. 2018 Jan 24;6(1):75-89.e11.
Altamura S, Kopf S, Schmidt J, Müdder K, da Silva AR, Nawroth P, Muckenthaler MU. Uncoupled iron homeostasis in type 2 diabetes mellitus. J Mol Med (Berl). 2017 Dec;95(12):1387-1398.
Muckenthaler MU, Rivella S, Hentze MW, Galy B. A Red Carpet for Iron Metabolism. Cell. 2017 Jan 26;168(3):344-361.
Baschant U, Rauner M, Balaian E, Weidner H, Roetto A, Platzbecker U, Hofbauer LC. Wnt5a is a key target for the pro-osteogenic effects of iron chelation on osteoblast progenitors. Haematologica. 2016 Dec;101(12):1499-1507.
Wrobel E, Rothenberg I, Krisp C, Hundt F, Fraenzel B, Eckey K, Linders JT, Gallacher DJ, Towart R, Pott L, Pusch M, Yang T, Roden DM, Kurata HT, Schulze-Bahr E, Strutz-Seebohm N, Wolters D, Seebohm G. KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting. Nat Commun. 2016 Oct 12;7:12795.